Skip to main content
Fig. 1 | BMC Genomics

Fig. 1

From: In-depth comparative analysis of malaria parasite genomes reveals protein-coding genes linked to human disease in Plasmodium falciparum genome

Fig. 1

Identification of group-enriched genes by virtual genome method. a Workflow of our comparative analysis. Protein sequence alignment was performed using phmmer to construct a protein similarity network where each edge represents a significant hit between query and target. Then, a modified BGLL algorithm was applied to find clusters within this network. Each cluster was considered as a virtual gene. Genes within these clusters were allocated to the species from which they originated, subsequently generating enriched values of all clusters in six species. Group-enriched genes can be identified by comparing cluster values in ingroup species with those in outgroup species. b The number of edges and the number of components included in the protein similarity networks that were obtained under different thresholds. c The number of clusters identified by the modified BGLL algorithm using different cut-off values of modularity. The arrow indicates the cut-off value used in this study. d Principal component analyses (PCA) of the enriched values of all clusters in six Plasmodium species. Components 1 (PC1) and 2 (PC2) represent 79% and 9% of total variance, respectively

Back to article page