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Fig. 5 | BMC Genomics

Fig. 5

From: BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues

Fig. 5

Imputation reduces discordance between WGBS and EPIC methylation estimates at low sequencing depth. (a) Root-mean squared discordance (RMSD) between EPIC and WGBS methylation (beta) estimates at CpGs common between the two platforms. X-axis: depth at which the CpG was sequenced, binned into intervals of 5× coverage. Y-axis: the beta value of the CpG as measured by the EPIC array, binned into intervals of 0.05. Yellow color indicates higher discordance. (b) RMSD between EPIC and imputed WGBS values at the same CpGs as in a. (c) Difference between a and b

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BMC Genomics

ISSN: 1471-2164

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