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Table 1 Selection of significantly altered genes by single-dose MDMA treatment in the different brain regions

From: Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

 

MinPplr

Fold Change (on log2 scale)

Frontal Cortex

Camk2g

Calcium/calmodulin-dependent protein kinase II gamma

0.000127

0.900

Camk1g

Calcium/calmodulin-dependent protein kinase I gamma

0.000174

0.383

Grin2b

Glutamate receptor, ionotropic, NMDA2B (Grin2b)

0.000395

0.448

Hspca

Heat shock protein 90α

0.000677

−0.398

Slc1a3

Solute carrier family 1 (glial high affinity glutamate transporter), member 3

0.000417

−0.724

Hippocampus

Gria3

Glutamate receptor, ionotropic, AMPA3

5.23E-05

−0.916

Grin2a

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A

5.42E-08

−1.610

Camk2g

Calcium/calmodulin-dependent protein kinase II gamma

1.46E-08

−1.451

Camk2b

Calcium/calmodulin-dependent protein kinase II beta

1.02E-08

−1.751

Kalrn

Kalirin, RhoGEF kinase

2.69E-05

−0.419

LOC316539

Eph receptor A4

1.82E-05

−0.729

Epha5

Eph receptor A5

3.29E-09

−1.065

Epha6

Eph receptor A6

7.39E-05

−0.484

Camk2n2

Calcium/calmodulin-dependent protein kinase II inhibitor 2

3.44E-06

0.345

Gabre

Gamma-aminobutyric acid A receptor, epsilon

0.000525

0.268

Atp2b3

ATPase, Ca++ transporting, plasma membrane 3

2.41E-12

−0.567

Atp2b1

ATPase, Ca++ transporting, plasma membrane 1

1.16E-05

−0.863

Slc5a3

Solute carrier family 5 (inositol transporters), member 3

9.94E-10

−1.356

Kcnd2

Potassium voltage gated channel, Shal-related family, member 2

7.56E-07

−1.476

Kcnc2

Potassium voltage gated channel, Shaw-related subfamily, member 2

6.11E-07

−0.905

Cnr1

Cannabinoid receptor 1

3.1E-06

−0.793

Dorsal Raphe

Slc6a5

Solute carrier family 6 (neurotransmitter transporter, glycine), member 5

0.000153

1.143

Hsd11b1

Hydroxysteroid 11-beta dehydrogenase 1

1.19E-08

0.450

Dao1

D-amino acid oxidase

0.000384

0.451

  1. This table summarizes the genes significantly (minimum probability of positive log ratio (MinPplr) < 0.001) altered in the frontal cortex (FC), hippocampus (HC) and dorsal raphe (DR) of Dark Agouti (DA) rats after a single-dose 3,4-methylenedioxymethamphetamine (MDMA) treatment (15 mg/kg, intraperitoneal) 3 weeks earlier. The genes were selected based on literature data and individual considerations, for all the significantly changed genes see Additional file 1: Table S1. See text for further details