Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

Table 2 Biologically Relevant Processes with Enriched Gene Sets in the Frontal Cortical Region

Biological Process	Number of Enriched Gene Sets Related to the Process	Direction
Protein synthesis and localization	21	⬇
Transmembrane transport	10	⬇
Nucleocytoplasmic transport	7	⬇
Cell growth	6	⬆⬇
Others	4	⬆⬇
Chromatin maintenance	3	⬇
Dendrite and synapse development	3	⬆
Oxidoreductase activity	2	⬇

This table summarizes the biological processes significantly altered in the frontal cortex (FC) of Dark Agouti (DA) rats after a single-dose 3,4-methylenedioxymethamphetamine (MDMA) treatment (15 mg/kg, intraperitoneal) 3 weeks earlier. The processes were created based on the network analysis of gene set enrichment x analysis and individual considerations. All significantly enriched GO terms are included in one of the processes. Downward arrows represent down-, upward arrows represent upregulations. In some of the biological processes both up- and downregulated gene sets were present (mixed up- and downward arrows). See text for further details

ISSN: 1471-2164