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Table 4 Selected miRNAs in oEVs in Stage 1 and 4 and associated pathways and target genes

From: Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo

miRNAs

KEGG pathway

p-value

Examples Target Genes (Gene Symbol)

hsa-mir-10b-5p

Pyrimidine metabolism

0.0214

NME4,NME2,POLR2D,POLR2A,POLR1B,NME1,CMPK1

hsa-miR-423-3p

Fatty acid biosynthesis

0.0000

FASN, ACACA

Fatty acid metabolism

0.0000

FASN, ACACA, ACOX3, FADS2

hsa-miR-449a

Carbon metabolism

0.0286

TKT,GAPDH,GOT1,H6PD,MDH2,RPIA,ENO1,ALDOA,ADH5

HIF-1 signaling pathway

0.0390

NFKB1,GAPDH,LTBR,BCL2,ENO1,LDHA,PIK3CA,SLC2A1,MKNK2,ALDOA,SERPINE1

hsa-miR-375

Hippo signaling pathway

0.0000

YAP1,YWHAG,CCND2,MOB1B,YWHAB,WWC1,AMOT,FZD8,MPP5,FZD4,DLG4,

Amino sugar and nucleotide sugar metabolism

0.0390

PGM2,CMAS,UXS1,UGP2,HK2

hsa-miR-24-3p

Fatty acid biosynthesis

0.0000

FASN,MCAT,ACACA

Vitamin B6 metabolism

0.0001

PDXK,PNPO,PHOSPHO2

Endocytosis

0.0005

RNF41,PSD4,CHMP7,VPS45,SMAD2,CBL,DNM2,FGFR3,VTA1,AGAP3,CAV1,AP2B1,N

Hippo signaling pathway

0.0014

ACTB,GSK3B,FZD5,YWHAH,SMAD2,BTRC,APC,NF2,YWHAG,SMAD3,WWTR1,TGFB1,

Bacterial invasion of epithelial cells

0.0078

ACTB,ITGB1,CBL,DNM2,PIK3CB,CAV1,PXN,BCAR1,CLTC,CD2AP,CAV2,CTTN,PTK2,

TGF-beta signaling pathway

0.0228

SMAD2,ACVR1B,SMAD3,TGFB1,SKP1,MYC,EP300,IFNG,E2F4,CREBBP,TGFBR2,BMP4,

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

0.0343

HS6ST2,NDST1,HS6ST1,EXTL3,HS2ST1,HS6ST3

DNA replication

0.0343

CNA,FEN1,MCM4,MCM5,MCM7,RNASEH1,PRIM1,POLA1

RNA degradation

0.0423

PDCP1A,CNOT6,TOB2,CNOT4,DDX6,HSPD1,EXOSC3,EXOSC1,BTG2,DCP2,RQCD1,

hsa-miR-429

Axon guidance

0.0009

PAK2,PPP3R1,RHOA,KRAS,PPP3CA,PTK2,CFL2,RAC1,LIMK1,EFNA1

Fc gamma R-mediated phagocytosis

0.0350

CRKL,CRK,WASF3,PLCG1,CFL2,RAC1,LIMK1,ARF6

Steroid biosynthesis

0.0000

SC5D,MSMO1,DHCR24,LSS,FDFT1,LIPA

Antigen processing and presentation

0.0019

B2M,IFI30,HSPA4,HSP90AA1,HLA-C,HLA-B,NFYA,PSME2,CANX,PDIA3,HSPA8,

Progesterone-mediated oocyte maturation

0.0039

ADCY1,CCNB1,PGR,ADCY7,CCNA2,CDC25B,CPEB4,HSP90AA1,PDE3A,RAF1,

Gap junction

0.0346

ADCY1,ADCY7,GNAS,MAP2K5,RAF1,TUBB,TUBB6,CDK1,KRAS,TUBA8,GNA11

hsa-miR-34b-3p

Glycosaminoglycan degradation

0.0000

GNS,IDS,GLB1

hsa-miR-200b-3p

Ras signaling pathway

0.0043

KSR1,RASA2,SHC1,PAK2,ETS1,RALBP1,PLD1,RHOA,KRAS,PLCG1,REL,FLT1,

Neurotrophin signaling pathway

0.0273

CRKL,CRK,SHC1,FRS2,BCL2,RHOA,KRAS,RPS6KA5,PLCG1,JUN,KIDINS220

hsa-miR-92a-3p

Cell cycle

0.0000

GSK3B,PCNA,SMC1A,CCNB1,SMAD2,HDAC1,CCND2,DBF4,SMC3,CDKN1B,

Adherens junction

0.0000

ACTB,TGFBR1,WASL,SMAD2,IQGAP1,IGF1R,VCL,FYN,MLLT4,NLK,CDH1,S

Thyroid hormone signaling pathway

0.0011

ACTB,GSK3B,PRKCA,MED13L,NRAS,RCAN1,PIK3CB,HDAC1,MED13,NOTCH2

FoxO signaling pathway

0.0024

IRS2,BRAF,STAT3,TGFBR1,CCNB1,SMAD2,NRAS,STK4,GABARAPL2,PIK3CB,SETD7

RNA transport

0.0025

SAP18,GEMIN6,NUP153,TGS1,NUP210,XPOT,EIF3B,ELAC2,RPP14,EIF2S3,RNPS1

p53 signaling pathway

0.0045

CCNB1,BID,THBS1,CCND2,CDK1,GADD45A,CDK6,CHEK1,ATM,CCND1,CCNE2,SHISA5

Signaling pathways regulating pluripotency of stem cells

0.0178

PCGF6,JARID2,TCF3,GSK3B,STAT3,KAT6A,SMAD2,NRAS,INHBB,PIK3CB,WNT5A,TBX3

Protein processing in endoplasmic reticulum

0.0179

HSPA1A,EIF2AK1,RAD23B,ERO1L,NPLOC4,SEL1L,UBQLN1,SEC23A,SSR2,P4HB,XBP1

Notch signaling pathway

0.0190

HDAC1,CTBP1,DTX2,NOTCH2,HES1,HDAC2,KAT2A,RBPJ,KAT2B,EP300,CREBBP,MAML1

Spliceosome

0.0210

HSPA1A,LSM7,DDX23,SRSF5,PPIL1,U2SURP,EFTUD2,SF3B1,U2AF2,SNRPE,SF3A3

MAPK signaling pathway

0.0210

BRAF,DUSP4,PRKCA,HSPA1A,TGFBR1,NFKB1,NRAS,CRKL,STK4,ELK4,CRK,DUSP6

Wnt signaling pathway

0.0386

GSK3B,PRKCA,LRP6,TBL1X,BTRC,VANGL1,WNT5A,CTBP1,CCND2,FZD6,AXIN1,SKP1

Focal adhesion

0.0393

BRAF,ACTB,GSK3B,PRKCA,ITGB8,CRKL,CRK,THBS1,ITGA8,PIK3CB,PIP5K1C,PPP1CC

Biosynthesis of amino acids

0.0473

TKT,BCAT2,GAPDH,PHGDH,TALDO1,PKM,SHMT2,BCAT1,MTR,ENO1,GOT2,PFKM,ASS1

hsa-miR-151a-3p

Biosynthesis of unsaturated fatty acids

0.0000

PTPLB,ELOVL5,SCD

Fatty acid metabolism

0.0003

HADH, PTPLB,ACACA,SCD,ELOVL5

hsa-miR-30d-5p

Mucin type O-Glycan biosynthesis

0.0000

GALNT7,B4GALT5,ST3GAL1,GALNT6,GCNT3,GALNT1,GALNT3,GALNT2

Oocyte meiosis

0.0000

FBXO5,CAMK2D,PGR,BTRC,CALM1,CPEB4,YWHAG,PPP1CC,PPP3R1

Ubiquitin mediated proteolysis

0.0000

UBE2R2,BTRC,FBXW7,TRIM37,CUL2,NEDD4L,FZR1,PRPF19,MAP3K1

mRNA surveillance pathway

0.0317

MSI2,SAP18,PPP2R3A,EIF4A3,HBS1L,PPP1CC,CPSF2,CPSF6,PAPOLA

hsa-miR-125b-5p

ErbB signaling pathway

0.0016

PRKCA,ERBB2,NRAS,CRKL,CRK,PAK2,RAF1,CDKN1B,EIF4EBP1,ERBB3

Regulation of actin cytoskeleton

0.0135

SSH2,EZR,NRAS,CRKL,CRK,PIP5K1C,PAK2,ARHGEF12,PPP1CC,ACTG1

  1. Table shows selected miRNAs based on differential expression and high abundance in EVs in Stage 1 and Stage 4 and associated representative pathways and target genes