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Fig. 1 | BMC Genomics

Fig. 1

From: Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Fig. 1

Leading edge genes from top phase-effect gene sets show phase-independent induction but phase-dependent induction magnitude. The infection dependent host response was evaluated by microarray analysis of mRNA extracted from infected uterine tissue collected 6 h after initial treatment with 107 gonococci or PBS. Expression levels of leading edge genes from for top gene sets identified by infection-effect GSEA are presented; “Cytokine-Cytokine Receptor Interaction” (KEGG HSA04060) (a) and “Chemokine Receptors Bind Chemokines” (R-HSA-380108) (b). For each gene, expression values (log2(expression)) are normalized to a mean of zero and standard deviation of one (z-normalized) for visual representation so that red and blue indicate z-scores of ≥2 or ≤ − 2, respectively, and white indicates a z-score of 0 (row-wise mean). Genes are presented in descending significance of infection effect t statistic (top to bottom). (N = 4 per condition except N = 3 for PBS Estrus)

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