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Fig. 2 | BMC Genomics

Fig. 2

From: Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Fig. 2

Genes with significant phase:infection interaction effect cluster into distinct expression patterns. Reproductive phase dependent elements of the anti-GC host response were evaluated through identification of phase:infection effected genes within microarray analysis of mRNA extracted from infected uterine tissue collected 6 h after initial treatment with 107 gonococci or PBS. Expression levels of (a) All 416 genes with phase:infection FDR q < 0.25 were clustered based on their relative expression pattern across all samples. Clusters are indicated by colored sidebar and number. Rows represent genes, with log2(expression) values z-normalized (to a mean of zero and a standard deviation of one) across all samples. Colors are scaled so that red and blue indicate z-scores of ≥2 or ≤ − 2, respectively, and white indicates a z-score of 0 (row-wise mean). (b) Enlarged view of Cluster 1, comprised of genes induced specifically in estrus phase. (c) Enlarged view of Cluster 4, comprised of genes induced specifically in diestrus phase. N = 4 for all conditions except N = 3 for PBS Estrus

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