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Fig. 3 | BMC Genomics

Fig. 3

From: Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Fig. 3

Leading edge genes from top phase:infection interaction-effect gene sets. Transcript levels of leading edge genes, from GSEA identified top phase:infection interaction effect gene sets (a. Chemokine activity gene set [GO:0008009], b. Interferon alpha/beta signaling pathway [R-HSA-909733]), as measured 6 h after infection, are displayed by heatmap. Rows represent genes, with log2(expression) values z-normalized (to a mean of zero and a standard deviation of one) across all samples. Colors are scaled so that red and blue indicate z-scores of ≥2 or ≤ − 2, respectively, and white indicates a z-score of 0 (row-wise mean). Rows are arranged in descending order from top to bottom by phase:infection t statistic. N = 4 per condition except PBS estrus N = 3

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BMC Genomics

ISSN: 1471-2164

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