Fig. 3

Transcriptome of isolated human islets exposed to palmitate for 0, 4 and 12 h and 1, 2 and 7 days. Transcriptomics analysis was performed by using GeneChip® Human Transcriptome Array 2.0 from Affymetrix. Genes were defined as differentially expressed if they changed more than 1.3-fold after palmitate treatment with the significance level of p ≤ 0.05. Panel a. Number of up- and down-regulated genes. Panel b. Each color reflects DEGs that appear for the first time at a certain culture duration. Results are from 5 donors