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Table 3 Genes with evidence failing to support FDSIs (negative results)

From: Systematic evaluation of isoform function in literature reports of alternative splicing

Gene

Experimental method

Tissue/Cell Type

Reference (PubMed ID)

Ank3

Isoform-specific rescue

Neuron

25,552,556

Ar

Knockdown

Prostate cancer cell line

20,823,238

Ccnd1

Isoform-specific rescue

Embryonic fibroblast

21,200,149

Dab1

Isoform-specific rescue

Neuron

28,968,791

Dntt

Isoform-specific rescue

Bone marrow

11,136,823

FANCE

Isoform-specific rescue

Breast cancer cell line

26,277,624

FNBP1L

Isoform-specific rescue

MDCK cell line

26,063,734

Pcdha1

Isoform-specific rescue

Brain

18,973,563

PDE4D

Knockdown

Kidney

16,030,021, 17,673,687

PEX19

Isoform-specific rescue

Fibroblast

11,883,941

Pparg

Knockdown and isoform-specific rescue

Adipose

11,782,442

RAP1GSDS1

Knockdown

Breast cancer cell line

24,197,117

RREB1

Knockdown

Bladder

21,703,425

SIRT1

Knockdown

Colon cancer cell line

22,124,156

Smad2

Isoform-specific rescue

Embryonic stem cells

15,630,024

STAT1

Knockdown

Embryonic cells

21,914,475

  1. These genes had multiple isoforms tested however only one splice isoform caused a change in phenotype