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Table 4 Most genes with FDSIs have biochemically distinct splice isoforms

From: Systematic evaluation of isoform function in literature reports of alternative splicing

 

Types of distinctness

Human genes

Mouse genes

Distinct expression patterns

Cell-type-specific

AR, MADD

 

Developmental-stage-specific

CD44

Myh10, Robo3

Cellular localization

BIRC5, CSPP1, PRMT5, PML

Myh10, Rbfox1, Robo3, Sirt3

Tissue-specific

MST1R

Calca, Rock2

Other-condition-specific

BOK

 

Biochemically distinct

Protein domain

CFLAR, DPF3, EIF4G1, TICAM1, TP63

Lrp8

Dominant negative

BIRC5, HBS1L, KLF6, Nf1, PRMT5, STIM2, SUN1, TICAM

Enc1, Nf1, Robo3, Ryr3, Tp63

Protein terminus change

BCAR1, BDNF, EIF4G2, IL1RAP, PGAM5

Cacna1b, Mecp2, Oprm1, Pn4

UTR Change

BDNF

 
  1. Genes with FDSIs were categorized on functional type based on the literature that reported on the FDSIs using the scheme outlined in Fig. 1. Genes categorized as “distinct expression patterns” express FDSIs in specific conditions. Genes categorized as “biochemically distinct” have FDSIs whose functional distinctness is a consequence of biochemical differences in their final protein product. Genes can be categorized as both “distinct expression patterns” and “biochemically distinct” such as Myh10 and Robo3