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Fig. 6 | BMC Genomics

Fig. 6

From: Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation

Fig. 6

HDAC3 regulates enhancer activity. a RNA polymerase signals around enhancer centers in Hdac3 KO and WT samples. b Heatmap of log2-transformed fold changes of RNA polymerase ±1 kb from all enhancer centers with 50 bp bin size comparing Hdac3 KO and WT mouse livers. c Elevation of H3K9ac signal around upregulated and unchanged enhancers upon Hdac3 deletion. d ChIP-seq signatures of HDAC3 binding around the top 50, 100, and 150 significantly upregulated enhancers. e ChIP-seq signatures of Ncor1 binding around the top 50, 100, and 150 significantly upregulated enhancers

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