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Fig. 5 | BMC Genomics

Fig. 5

From: From mutations to mechanisms and dysfunction via computation and mining of protein energy landscapes

Fig. 5

a SDR-obtained local minima and saddles are shown superimposed over the WT landscape at bandwidth 0.7. Local minima are drawn as black dots, and saddles are drawn as yellow dots. b Reduced gradient curves are additionally plotted from local minima that lead to saddles. The reduced gradient curves tracked by following the first column of the Hessian matrix are colored in green, and the curves tracked by following the second column of the Hessian matrix are colored in blue

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