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Table 1 Genomic regions identified by genome-wide association analysis of resistance to clinical mastitis in Nordic Holstein cattle

From: Prioritizing candidate genes post-GWAS using multiple sources of data for mastitis resistance in dairy cattle

BTA

Base position

Effect

–log10(p)

Region***

Gene

Annotation

3

92,927,352

−1.34

8.88

91,961,838~ 93,178,041

ENSBTAG00000010814 (28,361 bp)

intergenic

4

10,928,348

−2.39

11.48

10,113,846 ~  11,178,507

TFPI2 (107,131 bp)

intergenic

4

58490979*

1.44

9.44

57,757,451 ~  58,741,047

ENSBTAG00000020620 (233,286 bp)

intergenic

5

30,211,323

−1.54

11.71

29,850,270 ~  30,461,626

BCDIN3 (599 bp)

upstream

5

106371995*

− 1.52

9.23

105,444,242 ~  106,622,012

CCND2 (95,176 bp)

intergenic

6

88,729,872

2.78

38.97

88,479,895 ~  88,980,376

GC

intron

6

23469606*

1.63

12.53

23,219,637 ~  23,719,758

MANBA

intron

6

93131207**

2.05

12.63

92,131,530 ~  93,382,644

CCDC158 (72,869 bp)

intergenic

7

57,794,761

1.36

9.32

57,545,197 ~  58,044,816

ENSBTAG00000019739 (33,697)

intergenic

8

25,684,799

1.83

11.98

25,434,812 ~  25,935,079

ADAMTSL1

intron

9

80,007,099

−1.45

10.02

79,238,565 ~  80,257,157

NMBR (604,558 bp)

intergenic

10

51,191,670

−1.63

9.90

50,733,332 ~  51,441,800

MYO1E

intron

11

88,742,878

1.47

9.43

88,150,188 ~  88,993,125

ID2

intergenic

13

62,017,506

−1.95

19.82

61,295,534 ~  62,267,717

PDRG1 (2545 bp)

upstream

14

61,344,981

1.76

8.88

61,020,081 ~  61,594,984

ZFPM2

intron

16

47,836,093

−1.88

12.77

47,048,599 ~  48,086,099

ACOT7

intron

18

43,909,571

2.38

17.52

43,659,734 ~  44,159,716

ENSBTAG00000004994 (17,651 bp)

intergenic

19

43,038,655

−1.73

14.95

42,148,461 ~  43,288,858

STAT5A

intron

20

38,471,456

−2.88

20.57

38,221,493 ~  38,721,830

SPEF2

intron

23

11,477,905

1.53

13.58

11,204,757 ~  11,727,945

MDGA1 (52,973 bp)

intergenic

25

35,354,412

1.46

9.47

35,104,498 ~  35,604,430

CUX1

intron

26

20,463,679

1.41

9.44

20,214,011 ~  20,713,741

SLC25A28 (2425 bp)

downstream

  1. *The lead SNP was found in the second round
  2. **The lead SNP was found in the third round
  3. ***The method to define the QTL interval can be found in Method