Table 1 Definitions of Boolean functions for the T-LGL leukemia Boolean network with 18 nodes [17, 18]
Node | Regulating function |
|---|---|
CTLA4 | TCR ∧¬ Apoptosis |
TCR | ¬ (CTLA4 ∨ Apoptosis) |
CREB | IFNG ∧¬ Apoptosis |
IFNG | ¬ (SMAD ∨ P2 ∨ Apoptosis) |
P2 | (IFNG ∨ P2) ∧¬ Apoptosis |
GPCR | S1P ∧¬ Apoptosis |
SMAD | GPCR ∧¬ Apoptosis |
Fas | ¬ (sFas ∨ Apoptosis) |
sFas | S1P ∧¬ Apoptosis |
Ceramide | Fas ∧¬ (S1P or Apoptosis) |
DISC | (Ceramide ∨ (Fas ∧¬ FLIP)) ∧¬ Apoptosis |
Caspase | ((BID ∧¬ IAP) ∨ DISC) ∧¬ Apoptosis |
FLIP | ¬ (DISC ∨ Apoptosis) |
BID | ¬ (MCL1 ∨ Apoptosis) |
IAP | ¬ (BID ∨ Apoptosis) |
MCL1 | ¬ (DISC ∨ Apoptosis) |
S1P | ¬ (Ceramide ∨ Apoptosis) |
Apoptosis | Caspase ∨ Apoptosis |