Table 2 Lists of the significantly enriched KEGG pathways associated with immune responses
Pathways | ID | DEGs No. | p-value | Up-regulated genes | Down-regulated genes |
|---|---|---|---|---|---|
Cytokine-cytokine receptor interaction | ko04060 | 29 | 5.04E-06 | CCL4,CCL3,CXCL10,IL17A,IL12B,IL19,IL10, XCL1,CCL5,CCL22,IL6,CCL20,GM-CSF,TNF, TNFRSF13C,TNFRSF8, TNFRSF9 | TNFSF12,CSF1R,regakine-1,CCL2,TNFRSF21, CSF3R,CCL24,CCL17,CCL14,IL5RA,CCL25, PPBP |
NOD-like receptor signaling pathway | ko04621 | 11 | 1.01E-05 | TNFAIP3,NFKBIA,IL6,TNF,CCL5 | CARD9,MAPK11,NLRP1,CCL2,MAPK13,NOD1 |
TNF signaling pathway | ko04668 | 15 | 5.59E-05 | TNF,NFKBIA,CCL5,IL6,TNFAIP3,EDN1,PTGS2,CCL20,ICAM1,GM-CSF,CXCL10 | MAPK11,CREB3L2,CCL2,MAPK13 |
Chemokine signaling pathway | ko04062 | 19 | 0.000168 | CCL3,CCL20,CXCL10,CCL4,CCL5,CCL22, XCL1,NFKBIA, GNG7 | CCL17,CCL24,PAK1,CCL25,regakine-1,CCL2,CCL14,GNB4,GNG12,PPBP |
Complement and coagulation cascades | ko04610 | 11 | 0.000286 | C3,SERPING1,CR2 | C1QA, C1QB,C1QC, CFD, F13A1,C5AR1, CD55, LOC102185401 |
Toll-like receptor signaling pathway | ko04620 | 13 | 0.000434 | IL12B,CCL3,CXCL10,TNF,NFKBIA,CCL4, CCL5,IL6 | CD14,MAPK11,CD86,regakine-1,MAPK13 |