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Table 3 Potentially essential proteins as acetylation targets for maintaining normal hepatic metabolism

From: Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease

Protein accession number

Protein name

All/Up/Downa

Protein subcellular localization

No. of interactive nodes in PPIb

No. of associated pathways

Signaling pathways

E1BMH4

EHHADH

2/1/1

mitochondria

53

11

Fatty acid degradation; Valine, leucine and isoleucine degradation; Tryptophan metabolism; Peroxisome; beta-Alanine metabolism; Butanoate metabolism; PPAR signaling pathway; Propanoate metabolism; Fatty acid metabolism; Lysine degradation; Carbon metabolism;

Q3SZ00

HADHA

14/12/2

mitochondria

48

11

Fatty acid degradation; Valine, leucine and isoleucine degradation; Tryptophan metabolism; beta-Alanine metabolism; Butanoate metabolism; Propanoate metabolism; Fatty acid elongation; Fatty acid metabolism; Biosynthesis of unsaturated fatty acids; Carbon metabolism; Lysine degradation;

Q29RZ0

ACAT1

10/10/0

mitochondria

20

12

Synthesis and degradation of ketone bodies; Fatty acid degradation; Valine, leucine and isoleucine degradation; Tryptophan metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Propanoate metabolism; Glyoxylate and dicarboxylate metabolism; Pyruvate metabolism; Fatty acid metabolism; Lysine degradation; Carbon metabolism;

Q32LG3

MDH2

6/6/0

mitochondria

20

5

Glyoxylate and dicarboxylate metabolism; Cysteine and methionine metabolism; Pyruvate metabolism; Citrate cycle (TCA cycle); Carbon metabolism;

P12344

GOT2

11/10/1

mitochondria

14

11

2-Oxocarboxylic acid metabolism; Alanine, aspartate and glutamate metabolism; Biosynthesis of amino acids; Arginine biosynthesis; Tyrosine metabolism; Arginine and proline metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Fat digestion and absorption; Cysteine and methionine metabolism; Carbon metabolism; Phenylalanine metabolism;

F1ML89

CPS1

11/10/1

mitochondria

12

5

Nitrogen metabolism; Alanine, aspartate and glutamate metabolism; Biosynthesis of amino acids; Arginine biosynthesis; Carbon metabolism;

Q2KIE6

HMGCS2

11/10/1

mitochondria

11

4

Synthesis and degradation of ketone bodies; Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis;

  1. a Number of all differentially acetylated sites (All) in the protein, higher acetylated sites (Up) and lower acetylated sites (Down) in the protein, separated by slash
  2. b Number of the nodes that were showing the reciprocally interactive proteins in the protein-protein interaction (PPI) network obtained by STRING analysis (shown as in Fig. 6 and/or Fig. S3)
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BMC Genomics

ISSN: 1471-2164

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