Fig. 2
From: mitch: multi-contrast pathway enrichment for multi-omics and single-cell profiling data
Multi-contrast enrichment analysis of RNA-seq with mitch. a The scoring metric, D, of every gene in the two contrasts, LG vs HG and HG vs HGVPA. b A filled contour plot of all genes after ranking. c Enrichment of Reactome gene sets in the two dimensional space. d Plot of gene set effect size (S) and significance. S is defined as the Pythagorean distance from the origin to each point in (c). Significance is measured as the -log10(FDR MANOVA). e Density plots for the three top significant gene sets (blue box) and three gene sets with largest effect size (red box)