Fig. 2

Evaluation of the reasonability of the identified marker genes. a Heatmap of expression of the marker genes. The expression was row-normalized (normalize each expression value by the sum over the row) across different cell types. The marker genes with the expression ≥0.6 are in red. Only the most biologically relevant two GO terms are shown for each module (Table S1). Hematopoietic stem cell (HSC), Multipotent progenitor (MPP), Lymphoid-primed multipotent progenitor (LMPP), Common Myeloid Progenitor (CMP), Granulocyte-monocyte progenitor (GMP), Megakaryocyte-erythrocyte progenitor (MEP), Monocytes (MONO), Erythroid progenitor (Ery), Common Lymphoid Progenitor (CLP), Natural killer cell (NK). b Venn diagram shows the overlapping of the marker genes by LinDeconSeq, MGFM and RNentropy on GSE74246 data set. c The distribution of the maximum expression of the identified marker genes among the given cell types. The thick line in the box represents the median value. The bottom and top of the boxes are the 25th and 75th percentiles (interquartile range). The whiskers encompass 1.5 times the interquartile range. d The distribution of the number of gold-standard marker genes in randomly chosen marker genes on the three datasets. The thick line in the box represents the median value. The bottom and top of the boxes are the 25th and 75th percentiles (interquartile range). The whiskers encompass 1.5 times the interquartile range. The statistical difference of the two groups was compared through the Wilcox test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001