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Fig. 4 | BMC Genomics

Fig. 4

From: A deconvolution method and its application in analyzing the cellular fractions in acute myeloid leukemia samples

Fig. 4

Two new AML subgroups revealed with the cell type fractions in the TCGA-AML data. Heatmap of the cell type fractions in the subgroups in TCGA-AML samples. a The subgroups are derived using PAM clustering method with the cell type fractions. Row represents TCGA-AML sample and column is cell type. b Kaplan–Meier curves for overall survival of the AML two subgroups for 179 TCGA-AML samples. P-value was from log-rank test. c PCCs between the cellular fraction and the expression of DEG across the 179 TCGA-AML samples. The subgroups show that the DEGs are associated with a particular function. d Kaplan–Meier curves for overall survival for the two subgroups that are predicted Random Forest classifier on the TARGET-AML data. The classifier is trained with the cell type fractions in TCGA-AML data. e The fractions of 13 primary blood cell types in the predicted subgroups for TARGET-AML samples. Within each subgroup, each scatter represents the fraction of a specific cell type. The statistical difference of the two groups was compared through the Wilcox test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001

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