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Table 3 Summary of gene, composition, and functional enrichment of KEGG pathways of genes in co-expression clusters (FDR <1e-05) in the Main Cows dataset

From: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

Cluster

No. of MtMP genes

No. of NuMP

Genes

No. of Non-MP genes

Total No. of genes

Enrichment of pathways

I

(NuMP-MtMP

Cluster)

13

216

584

813

Parkinson’s disease, Oxidative phosphorylation,

Alzheimer’s diseases, Huntington diseases, Non-alcohol fatty liver diseases, metabolic pathways, Citrate cycle, carbon metabolism, Cardiac muscle contraction, Proteosome

II

0

10

871

881

Retrograde endocannabinoid signaling,

GABAergic synapse, Nicotine addiction, Morphine addictions, Glutamatergic synapse,

Dopaminergic synapse, Synaptic vesicle cycle, Neuroactive ligand-receptor interaction

III

0

12

923

935

Cell adhesion molecules (CAMs), Staphylococcus aureus infection, intestinal immune network for IgA production, Leishmaniasis, Antigen processing and presentation, viral myocarditis, Allograft rejection, primary immunodeficiency, Hematopioetic cell lineage, Natural killer cell-mediated cytotoxicity

IV

(NuMP cluster)

0

79

466

545

Chemical carcinogenesis,

Complement and coagulation cascade, Drug metabolism – cytochrome p450 metabolism, steroid hormone biosynthesis, retinol metabolism, Metabolic pathways, Complement and coagulation cascades, bile secretion, primary bile acid biosynthesis, tryptophan metabolism, carbon metabolism, fatty acid metabolism