Fig. 3

Detailed functional profiling of the DEGs whose expression significantly changed (P < 0.05, FC > 2 or < 0.5) between the IUGR and NBW piglets. a Classification of GO terms based on the functional annotation of BP enriched in the IUGR piglets on Day 1. The ordinate represents the GO item, the abscissa represents the number of enriched DEGs corresponding to each term, and the color column represents the enrichment score (defined as -Log10 P-value). b The GOCircle plot of IUGR piglets on Day 1. The outer circle shows a scatter plot for each term of the logFC of the assigned genes. The red circles indicate the upregulated genes and the blue circles indicate the down-regulated genes by default. c The GOChord plot of the IUGR piglets on Day 1. The DEGs that were assigned to at least three process terms were selected. d The tables show the major functions of the DEGs that were selected in the IUGR piglets on Day 1. e The protein-protein interaction network of the DEGs in the IUGR piglets on Day 1. The red nodes indicate gene upregulation and the green nodes indicate downregulation in IUGR piglets. Fold changes (FC) in expression are expressed as log2 (FC) values. f GO enrichment analysis of the DEGs of BP enriched in the IUGR piglets on Day 7. g GO enrichment analysis of the DEGs of BP enriched in the IUGR piglets on Day 28. h Enriched KEGG pathways (Top 15) for the DEGs that were significantly altered in the IUGR piglets during postnatal development