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Table 4 Biological pathways significantly associated with genes in which SNPs from Low- and High-RFI were localized

From: Development and comparison of RNA-sequencing pipelines for more accurate SNP identification: practical example of functional SNP detection associated with feed efficiency in Nellore beef cattle

Pathway Name

p-value

FDRi

Genes associated with SNPs detected

Function

Low-RFIii

 Members of the BCRa signaling

1.68 × 10−6

5.12 × 10−3

20

Immune

 Oxytocin signaling

1.70 × 10−5

1.87 × 10−2

42

Reproduction and Metabolism

 EPHA2b forward signaling

2.72 × 10−5

1.87 × 10−2

10

Growth and Metabolism

High-RFI

 Members of the BCR signaling

1.21 × 10−5

1.52 × 10−2

19

Immune

 B cell activation

1.313 × 10−5

1.52 × 10−2

22

Immune

 Regulation of RAC1c activity

1.48 × 10−5

1.52 × 10−2

17

Metabolism

  1. i FDR False Discovery Rate
  2. ii Top 3 pathways out of 111 significantly associated pathways
  3. a BCR B Cell Receptor
  4. b EPHA2 Ephrin type-A receptor 2
  5. c RAC1 Ras-related C3 botulinum toxin substrate 1