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Fig. 3 | BMC Genomics

Fig. 3

From: Analysing the meta-interaction between pathways by gene set topological impact analysis

Fig. 3

Assembly of enriched pathways from two real datasets based on GESTIA scores. a. The directed weighted network constructed using the GESTIA scores of the enriched pathways in Lin et al. 2018. Red vertices represent pathways that were up-regulated, and blue vertices represent down-regulated pathways. b. Visualization of the gene interactions between BIOCARTA_MAPK_PATHWAY and HALLMARK_XENOBIOTIC_METABOLISM (from MSigDB). Red vertices represent the genes in the first of the two pathways; the yellow ones represent genes in the second. To avoid overcomplicating the figure, we only showed the part of the figure where the two pathways interact with each other. c. Visualization of the gene interactions between GO_CELL_CYCLE and GO_MITOCHONDRIAL_ MEMBRANE_PART (from MSigDB). The color set of the vertices is the same as in b. d. The directed weighted network constructed using the GESTIA scores of the enriched pathways in Giustacchini et al. 2017. The color set of the vertices is the same as in a

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