Table 1 Results of functional investigations’ summarised for each of the three selected Mlincs
From: Long non-coding RNA exploration for mesenchymal stem cell characterisation
Mlinc | Predicted RNA-Protein interactions (lncADeep) | Subcompartment enrichment | FANTOM6 expr. changes | Diff. genes in positive cells | K-mers investigations |
|---|---|---|---|---|---|
Mlinc.28428 | Apoptosis, mRNA decay, PPARA activity, intracellular transport, response to hypoxia and cell cycle | Chromatin, cytoplasm | BOLA3-AS1, JPX, SERTAD4-AS1, PTCHD3P1, ERVK3.1, SNRPD3, MEG3 | H19, PI16 | Stress, senescence |
Mlinc.128022 | THY1, NRF1 | Chromatin, cytoplasm | FOXN3-AS1, A1BG-AS1, CD27-AS1, FLVCR1-AS1 | FTH1, TPM2, FTL, CD24, HMGN2, HMGB1, ODC1, PTTG1, BIRC5, EIF5A, MKI67, UBE2S, FGF5, HAS2-AS1 | Osteodiff., Stress |
Mlinc.89912 | MGMT-mediated DNA damage reversal, Nonsense Mediated Decay, Tubulin metabolism | nucleus (free), cytoplasm | NEAT1_1, PCAT6, MFI2-AS1, MKLN1-AS2, CDKN2B-AS1 | FGF5 and HIST1H4C | Proliferation |