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Fig. 8 | BMC Genomics

Fig. 8

From: scReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets

Fig. 8

a Permutation test for assessment of enrichment of trans scReQTLs in known gene-gene interactions obtained from the STRING database; 10,000 permutations were used. The p-value (p < 10e-4) was defined as the fraction of permutations in which the number of gene-gene pairs found in the known interaction database was at least as great as the number found in the observed data. This analysis showed significant enrichment of trans-scReQTLs with known gene-gene interactions. b and c) Examples of trans-scReQTLs and known gene-gene interactions: IFITM2 (11:309127_A > G) in and IFIT1 (b) and PLK1 (16_23690217_A > G) and AURKA, and CKS2 (9:89316518_T > C) and CDC20 (c). The interaction graphs are generated using the STRING database visualization tools. Note that all the scReQTL highlighted gene-gene interactions are supported by a minimum of three lines of evidence that include either experimental validation (purple line) or curated databases (light-blue line), or both

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