Fig. 6
![Fig. 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12864-020-6554-8/MediaObjects/12864_2020_6554_Fig6_HTML.png)
Cell-cycle GRNs based on important TF Features. (a, b) The GRNs consisting of TFs with the top 10th percentile weights for all cell-cycle expressed genes using TF-target interactions from ChIP (a), or Deletion (b) data. (c, d) The GRNs consisting of TFs in FFLs with the top 10th percentile weights for all cell-cycle expressed genes using ChIP (c) or deletion (d) data. Interactions are further annotated with the phase of cell-cycle expression they are important for (10th percentile of SVM weight in ChIP-chip models). Insert: Cell-cycle phase 1 = G1, 2 = S, 3 = S/G2, 4 = G2/M, 5 = M/G1. Red edges: new interactions identified compared to (c). In (a-d), node outline colors indicate TFs shared between GRNs in: orange - (a) and (b); pink - (a) and (c); blue – (b), (c), and (d); cyan - (c), and (d). Filled colors: four modules with TF-TF interactions important for expression in ≥2 phases. Red and green modules consist of known cell-cycle regulations, blue and purple modules consist of non-annotated cell cycle regulators