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Table 3 ECEA identified inversely changed Reactome pathways in the Glut4 data

From: Equivalent change enrichment analysis: assessing equivalent and inverse change in biological pathways between diverse experiments

Pathways

FDR

NES

Size

Top 5 Genes

GPCR ligand binding

1.72 × 10− 1

−1.40

219

Tshr,Ccr7,Ece1,Sstr1,Pth1r

Protein localization

2.29 × 10−1

−1.52

68

Dhrs4,Gstk1,Ech1,Slc25a17,Tysnd1

SLC-mediated transmembrane transport

6.69 × 10−2

−1.57

108

Slc26a2,Slc31a1,Slc2a4,Slco3a1,Slc39a8

Transport of inorganic cations/anions and amino acids/oligopeptides

7.00 × 10−2

−1.69

43

Slc26a2,Calm2,Slc7a8,Slc3a2,Slc4a8

Peroxisomal protein import

1.15 × 10−1

− 1.68

40

Dhrs4,Gstk1,Ech1,Tysnd1,Pex5

VEGFR2 mediated vascular permeability

1.29 × 10− 1

−1.73

21

Akt2,Calm2,Pak2,Ctnnb1,Nos3

Transcriptional Regulation by E2F6

4.01 × 10−2

−1.79

15

Phc1,Rbbp4,Ezh2,Ehmt2,Suz12

SHC-mediated cascade: FGFR2

2.03 × 10−1

− 1.68

17

Fgf4,Fgf8,Grb2,Fgf6,Fgf18