Equivalent change enrichment analysis: assessing equivalent and inverse change in biological pathways between diverse experiments

Table 5 ECEA identified equivalently changed KEGG pathways in the antidepressant data

Pathway	FDR	NES	Size	Top 5 Genes
mmu03010 Ribosome	1.01 × 10⁻²	1.52	95	Rpl7a,Rpsa,Rpl34,mt-Rnr1,Rplp1
mmu00230 Purine metabolism	2.12 × 10⁻¹	1.22	144	Ada,Nt5e,Adcy4,Ak7,Pde1c
mmu00500 Starch and sucrose metabolism	2.12 × 10⁻¹	1.47	22	Gaa,Amy1,Gys1,Pgm1,Pgm2
mmu00250 Alanine, aspartate and glutamate metabolism	2.12 × 10⁻¹	1.44	28	Gad2,Nit2,Aldh4a1,Gad1,Ass1
mmu04080 Neuroactive ligand-receptor interaction	5.36 × 10⁻²	1.24	185	Mc3r,Sstr5,Crhr2,Glp1r,Gabrq
mmu00340 Histidine metabolism	1.01 × 10⁻²	1.67	20	Aldh3b1,Aldh7a1,Hdc,Aldh3a1,Ddc

ISSN: 1471-2164