Fig. 6

Schematic representation of biosynthetic gene cluster 55 of T. reesei. The gene cluster is located on scaffold 19 (571843–660,892 nt) and contains 22 predicted genes and two possible pseudogenes. Gene A is a putative general substrate transporter, position B is a possible pseudogene, gene C a glycosyltransferase from the family 1, gene D is a putative MFS general substrate transporter, gene E is a HET-domain-containing protein, gene F is a sulfatase, gene G is a putative RiPP precursor peptide, gene H is a putative amino acid transporter, gene I is a chitinase, gene J is a putative GMC oxidoreductase, gene K is a casein kinase II alpha subunit, gene L is a putative alpha/beta-hydrolase, gene M is a GroES-like protein, gene N is an acid phosphatase, gene O is a hypothetical protein, gene P encodes for a cytochrome P450, gene Q is a putative NAD (P)-binding protein, gene R is a family 54 glycoside hydrolase, gene S is a putative carboxypeptidase S, gene T is a possible pseudogene, gene U is a putative class I glutamine amidotransferase-like protein, gene V is a PTH11-type GPCR and gene W is a GMC oxidoreductase. The gene annotations were manually curated and based on a Blastp v2.9.0+ (protein-protein BLAST) [25] search against the non-redundant protein database, the conserved region finder and a manually curated database (Additional file 5)