Fig. 3

Predicted tertiary structure of SMBS Cathepsin L 1 and 2 and comparison with Fasciola hepatica cathepsin L. aFasciola hepatica cathepsin L crystalised structure 2O6X showing hydrophobic residues (orange). b Sm_CL 1 predicted structure based on Phyre2 model aligned to F. hepatica pdb. c Sm_CL2 predicted structure based on Phyre2 model aligned to F. hepatica pdb. d-f Closer view of substrate binding site 2, D - F. hepatica cathepsin, E – Sm_CL1, F – Sm_CL2. g-i Charged residues white = neutral, red = negative, blue = positive of G - fasciola hepatica, H - Sm_CL1, I - Sm_CL2