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Table 2 Process and Pathway Enrichment Among Candidate Genes

From: The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster

PANTHER GO-Slim Biological Process

Gene Content

Input

Expected

Fold Enrichment

P-value

FDR

activation of adenylate cyclase activity (GO:0007190)

32

3*

0.07

46.09

4.69 × 10 − 5

0.0353

adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)

32

3*

0.07

46.09

4.69 × 10 −5

0.0235

cAMP-mediated signaling (GO:0019933)

41

3*

0.08

35.98

9.38 × 10 −5

0.0282

regulation of cAMP-mediated signaling (GO:0043949)

41

3*

0.08

35.98

9.38 × 10 −5

0.0235

regulation of adenylate cyclase activity (GO:0045761)

42

3*

0.09

35.12

1.00 × 10 −4

0.0216

regulation of lyase activity (GO:0051339)

43

3*

0.09

34.3

1.07 × 10 −4

0.0201

cyclic-nucleotide-mediated signaling (GO:0019935)

50

3*

0.1

29.5

1.64 × 10 −4

0.0274

regulation of biological process (GO:0050789)

1359

11

2.76

3.98

3.87 × 10 −5

0.0582

biological regulation (GO:0065007)

1492

11

3.03

3.62

9.15 × 10 −5

0.0343

PANTHER Pathways

Gene Content

Input

Expected

Fold Enrichment

P-value

FDR

PDGF signaling pathway (P00047)

47

3

0.1

31.38

1.38 × 10−4

0.0213

Endothelin signaling pathway (P00019)

74

3*

0.15

19.93

0.0495

0.0256

  1. Enrichment analysis for the 29 genes associated with peroxide resistance. Gene Content is the number of genes in the respective process/pathway in the Drosophila genome (n = 13,767 genes in the GO database). Input is the number of resistance-associated genes in each process/pathway, and Expected is the number expected under the null hypothesis. Asterisks (*) indicate categories enriched due to the adenylyl cyclase X gene cluster