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Table 1 Functional enrichment for GCS-score results for dataset: GSE76700. Top GO categories returned from ToppFun suite

From: GCSscore: an R package for differential gene expression analysis in Affymetrix/Thermo-Fisher whole transcriptome microarrays

Category

ID

Name

p-value

FDR (B&H)

GO: Molecular Function

GO:0008144

drug binding

6.97E-05

2.11E-02

GO: Molecular Function

GO:0032559

adenyl ribonucleotide binding

8.10E-05

2.11E-02

GO: Molecular Function

GO:0030554

adenyl nucleotide binding

9.36E-05

2.11E-02

GO: Molecular Function

GO:0051020

GTPase binding

1.03E-04

2.11E-02

GO: Molecular Function

GO:0004351

glutamate decarboxylase activity

1.53E-04

2.13E-02

GO: Biological Process

GO:2001280

positive regulation of unsaturated fatty acid biosynthetic process

4.16E-06

1.91E-02

GO: Biological Process

GO:0045723

positive regulation of fatty acid biosynthetic process

1.62E-05

1.96E-02

GO: Biological Process

GO:0045923

positive regulation of fatty acid metabolic process

1.63E-05

1.96E-02

GO: Biological Process

GO:0099536

synaptic signaling

1.79E-05

1.96E-02

GO: Biological Process

GO:0098916

anterograde trans-synaptic signaling

3.25E-05

1.96E-02

GO: Cellular Component

GO:0030136

clathrin-coated vesicle

6.26E-07

3.52E-04

GO: Cellular Component

GO:0045202

synapse

1.20E-05

2.68E-03

GO: Cellular Component

GO:0030135

coated vesicle

1.43E-05

2.68E-03

GO: Cellular Component

GO:0005938

cell cortex

2.67E-05

3.76E-03

GO: Cellular Component

GO:0030054

cell junction

5.85E-05

5.70E-03

Pathway

1,268,766

Transmission across Chemical Synapses

2.54E-06

3.70E-03

Pathway

P00018

EGF receptor signaling pathway

2.70E-05

1.62E-02

Pathway

377,263

GABAergic synapse

3.34E-05

1.62E-02

Pathway

M8353

Human Cytomegalovirus and Map Kinase Pathways

7.95E-05

2.90E-02

Pathway

1,268,763

Neuronal System

1.37E-04

3.30E-02

Pathway

83,105

Pathways in cancer

1.52E-04

3.30E-02

Pathway

137,938

IL2 signaling events mediated by PI3K

1.61E-04

3.30E-02

Pathway

1,268,775

GABA synthesis

2.02E-04

3.30E-02

Drug

ctd: D003024

Clozapine

4.37E-11

1.06E-06

Drug

ctd: D020849

Raloxifene Hydrochloride

2.07E-10

2.01E-06

Drug

ctd: D004390

Chlorpyrifos

2.49E-10

2.01E-06

Drug

ctd: C548651

2-(1’H-indolo-3′-carbonyl)thiazole-4-carboxylic acid methyl ester

3.55E-09

2.15E-05

Drug

CID000005637

U0126

9.57E-09

4.65E-05

Disease

C0027051

Myocardial Infarction

1.98E-06

6.85E-03

Disease

C0006012

Borderline Personality Disorder

1.35E-05

2.29E-02

Disease

C0917798

Cerebral Ischemia

2.32E-05

2.29E-02

Disease

C0006287

Bronchopulmonary Dysplasia

2.65E-05

2.29E-02

Disease

C0001430

Adenoma

5.34E-05

3.69E-02

Disease

C0001973

Alcoholic Intoxication, Chronic

7.18E-05

4.14E-02