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Fig. 3 | BMC Genomics

Fig. 3

From: A novel missense mutation in the gene encoding major intrinsic protein (MIP) in a Giant panda with unilateral cataract formation

Fig. 3

The p.S229N mutation within the intracellular C-terminal domain of MIP affects protein hydrophobicity. a Multiple alignment of a highly-conserved sequence of 21 amino acids in five orthologs of MIP (panda, mouse, bovine, rat and human) showing that the panda p.S229N substitution affects a serine residue conserved across all species. b ProtScale analysis of the human protein with the equivalent mutation (p.S229N) confirming a decrease in overall hydrophobicity

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BMC Genomics

ISSN: 1471-2164

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