Skip to main content
Fig. 3 | BMC Genomics

Fig. 3

From: Unveiling the long non-coding RNA profile of porcine reproductive and respiratory syndrome virus-infected porcine alveolar macrophages

Fig. 3

DE lncRNAs in PAMs upon PRRSV infection. a Volcano plots of DE lncRNAs between mock and PRRSV-infected PAMs. Red or green points represent the DE lncRNAs with statistical significance (P < 0.05). b Unsupervised hierarchical clustering and heat map of lncRNA expression between mock and PRRSV-infected PAMs. Each column represents a sample and each row represents a lncRNA. Red color indicates relatively high expression and blue color indicates relatively low expression. c Verification of lncRNAs expression in mock and PRRSV-infected PAMs. Expression levels of four upregulated and one downregulated lncRNAs were verified by qPCR and normalized to β-actin. The results were presented as the fold change to the corresponding uninfected control (*, P < 0.05). d and e Pathway analysis of DE lncRNAs after PRRSV infection. The dot plots represent the enrichment of the lncRNAs in each pathway. The color of each dot corresponds to the P-value. The size of each dot shows the number of lncRNAs. The horizontal axis represents the enrichment level of the pathways. A higher enrichment level means a larger change after PRRSV infection when the P-values are the same. Pathway enrichment of upregulated lncRNAs (d) and downregulated lncRNAs (e) was shown respectively. Results are representative of three independent experiments (means ± SD). *, P < 0.05. The P value was calculated using Student’s t-test

Back to article page