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Fig. 4 | BMC Genomics

Fig. 4

From: Mitochondrial genotype alters the impact of rapamycin on the transcriptional response to nutrients in Drosophila

Fig. 4

Functional mapping of opposing expression profiles in OXPHOS genes. The functional roles of OXPHOS genes with mitonuclear genotype mediated significant differential expression in response to refeeding with rapamycin. Genes were visualized in the OXPHOS metabolic pathway using the Kaneisha Laboratories online tool KEGG mapper (https://www.kegg.jp/kegg/tool/map_pathway2.html) [37]. KEGG pathway nodes are color-coded to correspond with their expression profile. Red nodes indicate that only genes from the “cluster 1” expression profile were associated, blue nodes indicate only “cluster 5”, purple nodes indicate both “cluster 1” and “cluster 5”, grey nodes indicate genes encoded by the mtDNA, green nodes indicate the associated genes were not differentially expressed and white nodes indicate there are no associated D. melanogaster genes. Copyright permission for image publication was obtained from Kanehisa Laboratories for KEGG pathway map ID 00190 “Oxidative Phosphorylation” copyright Kanehisa Laboratories [33,34,35, 37]

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