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Table 2 Drugs to which breast cancer subtype(s) in TCGA samples were predicted to be sensitive. The lowest predicted ln (IC50) values among the subtypes are in bold

From: Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines

Drug

Median Predicted ln (IC50) value (Number of samples)

ID

Name

Target

Basal-like (191)

Her2-pos (82)

Luminal A (567)

Luminal B (219)

Normal-like (41)

1378

Bleomycin

DNA

2.482

3.225

3.186

3.371

2.775

1248

Daporinad

NAMPT

−2.439

−1.441

−1.665

−1.768

−1.864

268

Sepantronium br.

BIRC5

−3.622

−3.388

−2.824

− 3.040

− 2.957

134

Etoposide

TOP2

1.734

2.344

2.403

2.369

2.073

1266

ICL1100013

NMT1

2.443

3.032

2.988

3.064

2.822

1910

ABT737

BCL2

2.037

2.176

1.500

1.401

1.940

1011

Navitoclax

BCL2

1.873

1.951

1.357

1.188

1.693

1594

OSI-027

mTOR

2.928

2.444

2.829

2.748

2.842