Table 3 KEGG molecular pathways enriched using differentially expressed genes in the mammary parenchyma of T20 vs CTL gilts

Metabolic pathways

77

ACAT1, ACSL3, ACSL6, ACSS3, ADSSL1, AGPAT3, AKR1B1, ALDH1B1, ALDH2, ALDH6A1, AMPD3, AMT, ANPEP, AOX1, ATIC, ATP6V1D, B3GALT2, B3GALT5, BDH1, C1GALT1, CDS1, CHDH, CKMT2, CRLS1, CYP4A24, CYP27A1, CYP27B1, CYP51, DGUOK, DNMT3A, DNMT3B, FAH, FPGS, GALNT3, GALNT15,GCLC,GFPT1,HIBCH, HPRT1, HSD17B7,HSD17B8, IMPDH2, LALBA, LCLAT1, LIPG, LIPT1, LPIN2, LSS, LTA4H, MAN1A1, MAN1A2, MAN1C1, MAN2A1, MAOB, MOCS1, MTMR2, NT5E, OCRL, PAPSS2, PIK3C3, PLB1, PLCH1, PMM1, PRDX6, PSAT1, SCP2, SGMS2, SHMT2, SRM, ST3GAL1, ST3GAL5, ST6GAL1, ST6GAL2, SUCLG1, UGT8, UXS1, XDH

1.6

1.7E-5**

Jak-STAT signaling pathway

16

CCND1, CCND2, CISH, CSF2RA, GHR, IFN-ALPHA-9, IFNGR2, IL2RG, IL6R, IL13RA1, MYC, OSMR, PIM1, PRLR, PTPN6, STAT3

2.7

6.7E-4†

PI3K-Akt signaling pathway

26

CCND1, CCND2, CHRM1, CREB3L1, EGF, GHR, GNB4, GNG2, HSP90AB1, IFN-ALPHA-9, IGF1R, IL2RG, IL6R, ITGA2, ITGB6, KITLG, MCL1, MYB, MYC, OSMR, PDGFC, PPP2R3A, PRLR, SPP1, TLR2, TLR4

1.9

2.1E-3

Ribosome

15

MRPL14, RPL5, RPL9, RPL10A, RPL11, RPL22, RPL24, RPL27, RPL31, RPL34, RPL35A, RPL36, RPS3, RPS3A, RPS20

2.5

2.2E-3

PPAR signaling pathway

9

ACSL3, ACSL6, ANGPTL4, CD36, CYP4A24, CYP27A1, DBI, SCD, SCP2

3.2

6.3E-3

Purine metabolism

15

ADCY1, ADSSL1, AMPD3, ATIC, DGUOK, GUCY1A3, HPRT1, IMPDH2, NT5E, NUDT5, PAPSS2, PDE4D, PDE6D, PDE9A, XDH

2.0

1.7E-2

Prolactin signaling pathway

8

CCND1, CCND2, CISH, FOS, PRLR, SHC4, STAT3, WAP

2.9

1.9E-2

Fatty acid degradation

6

ACAT1, ACSL3, ACSL6, ALDH1B1, ALDH2, CYP4A24

3.6

2.4E-2

Tryptophan metabolism

6

ACAT1, ALDH1B1, ALDH2, AOX1, CAT, MAOB

3.6

2.4E-2

Thyroid hormone synthesis

8

ADCY1, ATP1B2, CREB3L1, FXYD2, GPX1, HSPA5, PDIA4, SLC5A5

2.7

2.7E-2

Glycerolipid metabolism

7

AGPAT3, AKR1B1, ALDH1B1, ALDH2, LCLAT1, LIPG, LPIN2

2.9

3.0E-2

Fatty acid metabolism

6

ACAT1, ACSL3, ACSL6, ELOVL5, HACD3, SCD

3.2

3.8E-1

Valine, leucine and isoleucine degradation

6

ACAT1, ALDH1B1, ALDH2, ALDH6A1, AOX1, HIBCH

3.0

4.8E-2

Protein processing in endoplasmic reticulum

13

DERL3, DNAJB11, EDEM1, HSP90AB1, HSPA5, HYOU1, MAN1A1, MAN1A2, MAN1C1, PDIA4, SEC24A, SEC61A2, TXNDC5

2.0

3.3E-2

Phagosome

12

ATP6V1D, C3, CD14, CD36, CD209, FCGR2B, ITGA2, PIK3C3, SEC61A2, TLR2, TLR4, TUBA1C

2.0

3.5E-2