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An in-depth analysis of the genomes of the Q fever-causing bacterium Coxiella burnetii shows an evolutionary pattern based on the modification of existing genes, supporting a model of clonal expansion of established genotypes, with significant variation at protein level.
Methylation levels of N6-adenine (6mA) and N4-cytosine (4mC) observed in metazoan samples may be due to bacterial contamination or incorporation of methylated nucleosides from exogenous DNA.
Aims and scope
- Matteo Pasini, BioMed Central, UK
- Alexandria Latto, BioMed Central, UK
- Arwa Tawfiq, BioMed Central, UK
- Shane C Burgess, University of Arizona
- Leonid Bystrykh, University of Groningen
- Alexei Fedorov, University of Toledo
- Scott E Hemby, Wake Forest University
- David Lightfoot, Southern Illinois University at Carbondale
- Leonard Schalkwyk, King's College London
- Jacqueline Smith, The Roslin Institute
- Theo Smits, Zürich University for Applied Sciences
- Stefan Wiemann, German Cancer Research Center
Dr. Jacqueline Smith is a Career Track Fellow at The Roslin Institute in Edinburgh. She joined the Editorial Board of BMC Genomics in 2015.