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Table 3 Proteomic changes upon organophosphorus pesticide intoxication

From: Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans

      

Genomic Resultsf

Genea

Proteinsb

Description

Fold

Changec

Quant Fractsd

Total Fractse

MH

DH

FH

C29F5.1

NP_495267.1

unknown function

OP only

0

1

-1.2

5.6

5.5

C42D4.1

NP_501136.1

unknown function – predicted alpha-helical protein

OP only

0

2

14.8

5.4

6.7

C42D4.3

NP_501132.1

unknown function – contains fibronectin domain

OP only

0

2

4.9

4.3

5.0

cul-3

NP_503151.1

Cullin

OP only

0

1

-1.3

-1.4

-1.5

E04F6.5

NP_001022062.1 NP_001022063.1

Very-long-chain acyl-CoA dehydrogenase

OP only

0

1

1.1

1.0

-1.2

K03E5.2

NP_001021535.1 NP_001021536.1 NP_001040674.1

predicted calponin

OP only

0

2

-1.2

3.0

2.9

T28F4.5

NP_492102.1

homolog of Death Associated Protein 1

OP only

0

1

2.6

1.7

1.4

Y57G11A.3

NP_502756.1

unknown function – contains LIM domain

OP only

1

1

1.6

4.4

6.0

gei-7

NP_001021367.1 NP_503306.1

isocitrate lyase/malate synthase

3.0

4

4

3.3

4.5

3.8

C32D5.8

NP_001022003.1 NP_001022004.1

unknown function – contains thioredoxin domain

2.9

1

1

2.7

4.3

3.9

T19B10.2

NP_505848.1

unknown function

2.3

5

6

9.3

4.3

4.8

C06A8.3

NP_495640.1

homolog of OV-17 hypodermal antigen

2.2

4

6

2.4

2.1

2.2

nex-1

NP_498109.1

Annexin

2.2

3

4

2.2

2.8

2.3

ifb-1

NP_495136.1 NP_495137.1

intermediate filament, B

1.9

3

4

1.1

1.5

1.5

sap-1

NP_494763.1

U2-associated snRNP A' protein

1.8

1

1

-1.3

-1.3

-1.2

ZK909.3

NP_493608.2

guanosine polyphosphate pyrophosphohydrolase/synthase

1.8

1

1

3.7

2.5

2.5

pfn-3

NP_508205.1

Profiling

1.7

2

2

1.2

3.8

4.3

H34C03.2

NP_501035.1

ubiquitin C-terminal hydrolase

1.7

1

1

-1.2

-1.4

-1.3

spp-14

NP_001041271.1

saposin like protein family

1.6

1

1

   

unc-60c

NP_503427.2

cofilin – actin depolymerizing factor

1.6

2

2

1.9

1.8

1.8

tag-273a

NP_001023516.1

unknown function – contains LIM domain

1.5

1

1

-1.2

2.0

3.5

unc-87

NP_001021092.1 NP_001021093.1 NP_001021094.1

myofilament associated protein

1.5

4

6

-2.2

1.2

1.6

F22F7.1

NP_503577.1 NP_872194.1

uncharacterized membrane protein

-1.6

1

2

-2.5

-4.3

-4.4

ttr-16

NP_502060.1

transthyretin like family

-1.6

1

1

1.1

-1.0

1.0

dct-16

NP_507944.1

unknown function – daf-16 regulated

-1.7

2

4

-4.6

-4.8

-5.1

dsc-4

NP_499903.3

microsomal triglyceride transfer protein, large subunit

-1.7

1

3

-1.3

-2.4

-2.0

pmt-1

NP_494990.2 NP_494991.1 NP_871997.1

phosphoethanolamine N-methyltransferase

-1.7

2

3

1.9

1.5

1.3

ZK1127.10

NP_495449.1

cystathionine gamma-lyase

-1.8

1

3

-1.3

-1.7

-1.9

asp-1

NP_741677.1

aspartyl protease

-1.9

3

4

1.2

-1.3

-1.2

pod-2

NP_001022400.1 NP_001022401.1

acetyl-CoA carboxylase domain

-2.0

1

6

2.2

1.0

-1.2

asp-5

NP_505135.1

aspartyl protease

-2.2

2

2

-1.0

-1.3

-1.1

dct-18

NP_496755.1

unknown function – daf-16 regulated

-2.4

3

3

-2.2

-1.9

-1.9

F48E3.3

NP_509268.1

UDP-glucose:glycoprotein glucosyltransferase domain

Cont only

0

2

1.2

-1.2

-1.0

ifg-1

NP_001022259.1 NP_001022260.1

initiation factor 4G

Cont only

0

2

1.4

1.0

1.1

  1. a- Gene names and descriptions were derived from WormBase, release WS189 [46].
  2. b- NCBI protein accession number
  3. c- Protein fold change values for OP exposure. Proteins identified as "OP only" or "Cont only" were identified in at least 4 replicates of the OP-exposed or control samples and in no replicates of the other condition.
  4. d- Number of fractions in which quantitative comparisons were made
  5. e- Number of fractions in which protein was identified
  6. f- Gene expression fold change values for mefloquine (MH), dichlorvos (DH), and fenamiphos (FH) high concentration exposure. Gene expression levels for H34C03.2 were below signal to noise threshold.
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BMC Genomics

ISSN: 1471-2164

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