Figure 1

Heatmap of 531 genes differentially expressed in the aortas of angiotensin II treated mice that developed aneurysms (n = 5) versus those that did not develop aneurysms (n = 7). A complete list of the genes used for this analysis is provided in Additional File 3. Expression in the saline controls (n = 6) for each of these genes is also shown. Each line in the heatmap represents a gene with mean upregulated (red) or downregulated (green) expression for the three groups. Black colour denotes no change in expression. Different patterns of gene expression are indicated as Patterns 1–4 and associated gene lists are provided in Additional Files 6, 7, 8 and 9 and Table 4. A Volcano plot (two fold change, p < 0.05) comparing the aneurysm group with aneurysm resistant group was used to select genes for this analysis.