Skip to main content

Table 1 Summary of the included studies.

From: Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Study

Comparison

Design

Method

Mice

Genes identified

1

Paired supra and infrarenal aortas

Pooled samples

Codelink mouse whole genome bioarray (36227 genes)

10

Differentially expressed between AAA prone supra and infrarenal aorta

2

Whole aortas of mice exposed to angiotensin II that did and did not develop aneurysms and saline infused controls

Individual mice

Illumina mouse sentrix 6 microarray (46,628 genes).

18

Differentially expressed between the 3 groups revealing aneurysm-associated and "protective" genes

3

Suprarenal aortas of mice exposed to angiotensin II that did and did not develop aneurysms

Individual mice

ELISA and IHC

18*

Validate findings from the microarray in study 2 for Tnfrsf11b, Tgfb1, and inflammatory cell markers.

  1. * 10 further mice died and were excluded from this study.