A stochastic model for identifying differential gene pair co-expression patterns in prostate cancer progression

BMC Genomics

Table 2 Algorithm comparison for three methods

Features	Methods
	SIG method	ECF method	DAGA method
Measure of co-expression change	z-CC ratio	ECF-statistic	z-CC ratio
Analytical distribution	+	-	+
Progression consideration	+	-	-
Multiple test analysis	+	-	-
Gene specificity analysis	+	-	-
Gene pair duple confirmation	+	+	-

The symbols '+' and '-' represent existence and absence of the corresponding categories. Because the distribution for each gene is different, gene pair duple confirmation refers to a gene pair (A, B) could be identified only when gene A is chosen, the pair shows significant co-expression change; meanwhile, when gene B is chosen, the pair is also determined with significant differential co-expression between two progressive stages.

ISSN: 1471-2164