Figure 6

The KWII spectra for HDL (Figure 6A) and atherosclerotic lesion length (denoted by the variable Athr on the y -axis of Figure 6B). The p-values for each combination are shown against the bars. The plus symbol indicates that there is a human QTL reported for the orthologous region corresponding to the mouse marker and the minus symbol indicates that a human QTL has not been reported. For the two-variable combinations, the plus and minus symbols are placed in the same order as the y-axis labels. The A and H indicate if the marker is present in both the HDL and Atherosclerosis spectra. Figure 6C is a haploid human karyotype ideogram. To the right of each chromosome, the human orthologs of the HDL (red bars) and atherosclerotic streak length (yellow bars) associated mouse markers identified in our study are shown. To the left of each chromosome the human QTL for HDL (gray bars) and atherosclerotic disease (black bars) are shown. Chromosomes 21, X and Y contained no overlapping orthologs and their labels are shown in gray.