Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach

Table 9 miRNAs involvement in immune response [11]

miRNA	Functions	Targets
miR-15a	Decreased expression in chronic lymphocytic leukaemia	Bcl-2
miR-16	Binds to UA rich elements in 3' UTR and induces TNF alpha mRNA degradation	TNFα
miR-21	Increased expression in B-cell lymphoma and chronic lymphocytic leukaemia
miR-17-5p	Inhibits monocyte proliferation, differentiation and maturation	AML-1
miR-20a	Inhibits monocyte proliferation, differentiation and maturation	AML-1
miR-106a	Inhibits monocyte proliferation, differentiation and maturation	AML-1
miR-24	Inhibits replication of vesicular stomatitis virus
miR-29a	Down-regulated in B-cell chronic lymphocytic leukemia	Tcl-1
miR-122	Required for hepatitis C proliferation in liver
miR-125b	Expression downregulated by LPS and oscillations in expression after exposure to TNF alpha	TNFα
miR-146a	Expression induced in macropahges and epithilial following activation of TLR or exposure to TNF alpha and IL-1beta	IRAK1, TRAF6
miR-146b	LPS induced expression induced in macrophages	IRAK1, TRAF6
let-7i	Regulates TLR-4 and contributes to cholangiocyte immune responses
miR-181a	Positive regulator of B-cell development and CD4⁺ T-cell selection, activation and sensitivity	SHP-2, PTPN22, DUSP5, DUSP6

ISSN: 1471-2164