Figure 4
![Figure 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2164-11-199/MediaObjects/12864_2009_Article_2793_Fig4_HTML.jpg)
Effects of Tyk2 and LPS on genes with IRF/ISRE TFBS. Effects of (A) Tyk2 genotype (Wt minus Tyk2-/-), (B) LPS treatment (6 hours of LPS minus control), and (C) genotype by treatment interaction (difference in LPS induction between Wt and Tyk2-/-) on expression levels of genes containing the IRF/ISRE TFBS, plotted as NCs (y-axis) against relative ranks (absolute rank divided by the number of genes; x-axis). Thick solid lines represent NCs; thin solid lines the values of all genes (see Figure 1) in order to highlight the effects on genes with IRF/ISRE TFBS relative to all genes analyzed.