Comparative genome analysis of a large Dutch Legionella pneumophila strain collection identifies five markers highly correlated with clinical strains

Table 2 The 7 rules of the predictive model describing all relevant relationships between the 5 selected markers

Rule No.	Rule
1	If (LePn.011A2-b < LePn.019H4) then [not(LePn.011A2-b = LePn.010B12)] else [(LePn.011A2-b = LePn.024B1) and (LePn.008D6 = LePn.010B12)]
2	If (LePn.011A2-b < LePn.010B12) then [not(LePn.019H4 < LePn.024B1)] else [(LePn.008D6 > LePn.011A2-b) nor (LePn.008D6 < LePn.024B1)]
3	If (LePn.011A2-b < LePn.010B12) then [not(LePn.024B1 > LePn.019H4)] else [(LePn.010B12 < LePn.008D6) nor (LePn.024B1 > LePn.008D6)]
4	If (LePn.019H4 = LePn.008D6) then [(LePn.024B1 < = LePn.019H4)] else [(LePn.019H4 < LePn.024B1) nor (LePn.010B12 = LePn.011A2-b)]
5	If (LePn.019H4 = LePn.008D6) then [(LePn.008D6 > = LePn.024B1)] else [(LePn.010B12 < = LePn.011A2-b) nor (not (LePn.024B1 < = LePn.019H4))]
6	If (LePn.019H4 = LePn.008D6) then [not(LePn.024B1 > LePn.019H4)] else [(LePn.024B1 > LePn.019H4) nor (LePn.011A2-b > = LePn.010B12
7	If (LePn.019H4 = LePn.008D6) then [not(LePn.019H4 < LePn.024B1)] else [(LePn.010B12 = LePn.011A2-b) nor (LePn.019H4 < LePn.024B1)]

The 7 rules of the predictive model describing all relevant relationships between the 5 selected markers. Each rule "votes" for a sample as being a clinical sample if the result of the rule evaluates to 'True' when the Boolean value for each probe is entered. If 4 or more rules in the table agree that a given sample is clinical, then the "meta-rule" of these 7 rules predicts that the sample is clinical.

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