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Table 3 Genes identified as putative Pros targets and their manual annotation

From: Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth

Genes

symbol

Biological function in larvae (manual annotation)

Cell fate commitment (GO:0045165, p = 0.0003)

αEst1*

CG1031

Sensory neuron morphogenesis

Art3*

CG6563

Not studied in larvae

Ash2*

CG6677

Neurite outgrowth, synapse formation, growth, sensory organ development

CG10632*

CG10632

Unknown

CG10671*

CG10671

Unknown

CG3021*

CG3021

Unknown

CG31637*

CG31637

Unknown

CG31961*

CG31961

Unknown

CG31731*

CG31731

Unknown

CG6388

CG6388

Neurite outgrowth

CG7878*

CG7878

Unknown

CG8155*

CG8155

Unknown

DPAL1*

CG12130

Neuropeptide biosynthesis

FK506-bp1*

CG6226

Autophagy; growth

Ftz-F1*

CG4059

Autophagy, sensory organ formation, olfaction

Hb*

CG9786

Labial segment formation including sense organ

Iap2*

CG8293

Autophagy, sensory organ development

Inx3*

CG1448

Not studied in larvae

Keren*

CG32179

Autophagy, sensory organ development

Mbo*

CG6819

Tracheal system development

Nak*

CG10637

Not studied in larvae

Nej *

CG15319

Synaptic transmission, autophagy

Notch*

CG3936

Neurite outgrowth, nutrient sensing/growth, sense organ formation, olfaction

Pelo*

CG3959

Not studied in larvae

Psq*

CG2368

Sensory organ development, olfaction

Rac1*

CG2248

Neurite outgrowth, sensory organ development

Tollo*

CG6890

Synaptogenesis, wing development, immune response

TFIIs*

CG3710

Not studied in larvae

LK6

CG17342

Autophagy growth, nutrient sensor mechanism,

Proteasome complex (GO:0000502, p < 10 -5 ,)

Pros 26.4

CG5289

Neuronal remodelling, Autophagy

Prosβ2

CG3329

Neuronal remodelling, Synaptic transmission, autophagy, sensory organ formation

Pros26

CG4097

Neuronal remodelling, Synaptic transmission, autophagy

Prosα6

CG18495

Neuronal remodelling, Synaptic transmission, autophagy

Prosα7

CG1519

Neuronal remodelling, Synaptic transmission, autophagy

ProsMA5

CG10938

Not studied in larvae

RPN1

CG7762

Neuronal remodelling, Autophagy

RPN2

CG11888

Neuronal remodelling, Autophagy

RPN5

CG1100

Neuronal remodelling, Autophagy

Signal transduction (GO:0004871, p = 0.0008)

Bnl

CG4608

Neurite outgrowth

CaMKI

CG1495

Synaptic transmission

CG10011

CG10011

Unknown

CG10702

CG10702

Autophagy

CG1088

CG10882

Unknown

CG31714

CG31714

Unknown

CG4839

CG4839

Unknown

CG5790

CG5790

Unknown

CG7536

CG7536

Unknown

CG7800

CG7800

Unknown

CKII α

CG17520

Sensory organ development

Dok

CG2079

Sensory organ development

EGFR

CG10079

Neurite outgrowth, synapse formation, growth, autophagy sensory organ development, olfaction

feo

CG11207

Mitotic spindle organisation

Gek

CG4012

Actin polymerisation

Gwl

CG7719

Neurite outgrowth, synaptic transmission, mitotic cell cycle

InaC

CG6518

Not studied in larvae

Kdelr

CG5183

Not studied in larvae

LimK1

CG1848

Neurite outgrowth, synaptic transmission

Lok

CG10895

Cell cycle, DNA damage checkpoint

Loco

CG5248

Not studied in larvae

Mcr

CG7586

Olfaction

PhKγ

CG1830

Not studied in larvae

Pvr

CG8222

Hemocyte formation, dorsal closure, macrochaete formation

Rh7

CG5638

Not studied in larvae

Toll-6

CG7250

Not studied in larvae

  1. The 64 genes found highly correlated in the peak 1, 2 and 3 are grouped according to their respective GO annotation class. The most significant classes of genes enriched in our list are "Cell fate commitment", "proteasome complex" and "signal transduction". The p value indicates the probability for a given ontology to be associated at random to this cluster. The first 28 genes indicated in bold and by an asterisk share a common DNA motif (CAGCTG) in their promoter and were also found to be differentially expressed between V1 and V14 CNS.
  2. The last column on the right specifies the known biological function (manual annotation) of these genes in the Drosophila larvae (Full references can be found in the main text and in [Additional file 5: Supplemental Tables S2-S4]). This manual annotation allowed the attribution of biological function to 37 genes. Some genes have either never been studied in larvae or their respective functions are currently unknown. By contrast to the GO annotation (mostly deduced from embryos), the use of manual annotation indicates that the dysfunction of pros leads in larvae to the misregulation of genes that mostly deal with neurite outgrowth, growth and autophagy and sensory organ formation (mainly olfactory). All genes were found to be overexpressed in the mutant V1 AMC except for the 9 genes associated with the Proteasome complex GO annotation.
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BMC Genomics

ISSN: 1471-2164

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