From: Identification of interacting transcription factors regulating tissue gene expression in human
Tissue | # tissue TF pair | # tissue Unique TF pair | Top 5 tissue TF pairs | Literature support |
---|---|---|---|---|
Fetal liver | 150 | 17 | HNF3:HNF4ALPHA**, MYOGNF1:PPARA*, PPARA:PAX2*, HNF1:OCT4*, CMAF:COUP_DR1* | [4] |
Liver | 162 | 18 | CEBPGAMMA:HNF4ALPHA**, HNF4ALPHA:HNF4ALPHA**, CEBPGAMMA:CEBPGAMMA*, AIRE:HNF3*, HNF3B:RUSH1A* | |
Fetal lung | 149 | 9 | CEBP:HNF4ALPHA**, CEBP:CEBPA**, VDR:OCT, CEBPGAMMA:PLZF, FOXJ2:GATA4 | |
Lung | 111 | 8 | EBOX:HNF4ALPHA**, CEBP:ETS**, SP3:WT1*, CACD:CETS1P54, EBOX:SPZ1 | |
Kidney | 173 | 15 | HNF3:HNF4ALPHA**, PPARA:SP3, AP2:HAND1E47, AP2:ER, TEL2:SREBP | [4] |
Pancreas | 146 | 14 | HNF3:HNF4ALPHA**, AP2:TBP*, DEC:MYOGNF1, GATA4:PAX4*, HNF4ALPHA:YY1 | [4] |
Pancreatic islets | 125 | 9 | SP1:SREBP1**, E2A:ZF5_B*, CP2:CP2, CHOP:OCT1, OCT:RUSH1A | Â |
Cardiac myocytes | 139 | 12 | HNF3:HNF3B**, CEBP:PAX4, POU3F2:PAX4, NFAT:SP3, TST1:SREBP1 | [4] |
Heart | 130 | 10 | MYOGNF1:SP3*, CP2:ZIC3, AP2:TAXCREB, TAL1BETAE47:MAF, FAC1:OCT1 | Â |
Skeletal muscle | 121 | 15 | OCT1:SP1**, MYOGNF1:DR4*, NKX25:TBP*, TEL2:ZIC3, AP2ALPHA:CP2 | [44] |
Smooth muscle | 137 | 10 | HMGIY:OCT**, EGR1:MYOGNF1*, TST1:PAX2, AP2:TST1, POU3F2:CEBP | Â |
Tongue | 152 | 17 | CEBP:CEBPA**, HNF4ALPHA:SREBP1, MYOGNF1:VDR*, HIC1:MYOGNF1*, CP2:ZIC3 | [41] |
Uterus | 144 | 12 | AP1:HMGIY**, HAND1E47:ZIC3*, PLZF:YY1*, AIRE:PLZF, SP3:WT | [45] |
Uterus corpus | 158 | 17 | HMGIY:OCT**, HNF3:MYOGNF1*, CP2:E2A*, NF1:SP1*, OCT4:TGIF | [46] |
Ciliary ganglion | 149 | 15 | AP1:STAT**, CACD:CETS1P54, MYOGNF1:NFY, CETS1P54:VDR, AP2:OCT4* | |
Dorsal root ganglion | 155 | 15 | CEBP:CEBPGAMMA**, FOXJ2:DR3, AREB6:FOXJ2, CEBP:TST1*, AP2ALPHA:GEN_INI3_B* | [41] |
Spinal cord | 144 | 6 | ETS:HMGIY**, HIC1:PPARA*, NKX25:PLZF, PPARA:TBP*, CART1:MYOGNF1 | [10] |
Superior cervical ganglion | 157 | 15 | CEBPGAMMA:HNF4ALPHA**, AP1:PLZF*, ETF:HOXA4*, FAC1:GATA4, DR3:TBP* | [3] |
Trigeminal ganglion | 166 | 18 | ETS:VDR**, TEL2:SPZ1, MINI19_B:PLZF, AP2ALPHA:PAX4*, CP2:TST1* | [49] |
Amygdala | 148 | 7 | OCT1:OCT1**, PAX:STAT*, EGR1:PAX2, AP2:CETS1P54*, MRF2:HMGIY | |
Caudate nucleus | 161 | 6 | CEBPGAMMA:CEBPGAMMA**, ETS:VDR**, AP2ALPHA:KROX*, GATA4:XVENT1, CEBPGAMMA:HMGIY | [41] |
Cerebellum | 149 | 11 | CEBPGAMMA:HMGIY, VDR:TAXCREB*, OSF2:PAX2, DR4:SPZ1*, FAC1:OCT4* | Â |
Cerebellum peduncles | 123 | 6 | CEBPGAMMA:CEBPGAMMA**, ETS:MYB**, ETS:VDR*, CART1:FAC1, DR4:SPZ1* | [41] |
Cingulate cortex | 131 | 3 | EBOX:ETS**, ETS:HMGIY**, NKX25:TBP*, MRF2:OCT4* AP2:XVENT1* | |
Fetal brain | 121 | 12 | ETS:HMGIY**, MINI19_B:SRY*, AHRARNT:VDR*, CACD:TAXCREB*, CDXA:HMGIY | [53] |
Globus pallidus | 145 | 8 | ETS:VDR**, NKX25:TBP*, NKX25:PAX5, AHRHIF:KROX*, AP2:SREBP* | [49] |
Hypotalamus | 134 | 5 | ETS:HMGIY**, CEBPGAMMA:CEBPGAMMA**, AP2:PPARA*, AP2:PPARA*, PAX:SREBP1* | |
Medulla oblongata | 124 | 3 | VDR:TAXCREB*, CEBPGAMMA:HMGIY, AP2:ETF*, MAF:PAX4*, MYOGNF1:ZIC3 | Â |
Occipital lobe | 132 | 6 | AP2:XVENT1*, NKX25:TBP*, AP2:PPARA*, AP2ALPHA:KROX*, PAX:STAT* | Â |
Olfactory bulb | 155 | 7 | CEBPA:GRE_C, AP2:TST1*, OCT:TST1*, CEBPGAMMA:HMGIY, AP2:PAX4* | Â |
Parietal lobe | 125 | 2 | EBOX:ETS**, TTF1:VDR, AP2:XVENT1*, NKX25:TBP*, CP2:HIC1 | [52] |
Pons | 160 | 3 | ETS:HMGIY**, OCT1:OCT1**, ETS:VDR**, GATA:GATA4*, AP2:SREBP* | |
Prefrontal cortex | 131 | 6 | PAX:STAT*, AP2:XVENT1*, CMAF:SP3, TAL1BETAE47:PAX2, AHRHIF:KROX* | Â |
Subthalamic nucleus | 128 | 5 | OCT:PAX5*, NKX25:TBP*, AP2ALPHA:DR4*, AHRHIF:KROX*, CP2:ZIC3 | Â |
Temporal lobe | 138 | 8 | AP2:ETF*, PAX3:SP1*, POU3F2:MYOGNF1*, NKX25:TBP*, CETS1P54:HMGIY | Â |
Thalamus | 137 | 11 | PAX:STAT*, CEBPGAMMA:GEN_INI3_B, XVENT1:YY1, MAZ:VMYB, AP2ALPHA:PLZF* | Â |
Whole brain | 130 | 8 | CEBPGAMMA:CEBPGAMMA**, GATA:OCT4*, AP2:PPARA*, AP2:PPARA*, POU3F2:NFAT* | [41] |
BM CD105+ endothelial | 143 | 10 | OCT:STAT**, CEBPGAMMA:PLZF*, ER:TBP*, GRE_C:PPARA, M YOGNF1:SP1* | [54] |
BM CD34+ | 158 | 7 | ETS:HMGIY**, CEBPGAMMA:PLZF*, ETF:TST1*, ETS:RUSH1A*, TAL1BETAE47:SP3* | [53] |
BM CD71+ earlyerythroid | 145 | 8 | PAX4:YY1*, GEN_INI3_B:GEN_INI3_B, KROX:NF1*, NF1:SP1*, CP2:CP2 | Â |
BM_CD33+ myeloid | 164 | 16 | CEBP:CEBPA**, ETS:VDR**, AP2ALPHA:EGR1* P300:SREBP1, CETS1P54:VDR* | |
Bone marrow | 154 | 16 | CEBP:CEBPA**, DR4:SPZ1*, AP2:OCT4, VDR:SREBP*, DR3:WT1* | [41] |
Lymph node | 157 | 7 | MINI19_B:LRF, OCT4:PAX4, CP2:ZIC3, AP2ALPHA:TTF1, TAL1BETAE47:PPARA* | Â |
PB BDCA4+ dentritic cells | 159 | 9 | CEBPA:CEBPGAMMA**, KROX:PPARA*, CEBP:TST1*, TST1:PAX2*, DR3:P300* | [41] |
PB CD14+ monocytes | 146 | 9 | CEBP:CEBPA**, TFE:TST1*, NF1:PAX8, NF1:ZIC3, MYOGNF1:SP1* | [41] |
PB CD19+ Bcells | 143 | 5 | HMGIY:OCT**, DBP:TBP*, ETS:HOXA4*, CP2:CP2, RUSH1A:RUSH1A | [46] |
PB CD4+ Tcells | 161 | 10 | ETS:SP1**, CEBPGAMMA:CEBPGAMMA**, CP2:SZF11, FAC1:VMYB, AREB6:GATA4 | |
PB CD56+ NKCells | 125 | 10 | ETS:GRE_C, CEBPA:CEBPGAMMA**, OCT1:SPZ1* CEBP:TST1*, AP2:GRE_C | [41] |
PB CD8+ Tcells | 155 | 8 | ETS:SP1**, AREB6:GATA4, AP2ALPHA:MAZ, TTF1:OCT1_07*, KROX:XVENT1* | [55] |
Thymus | 164 | 11 | EBOX:HNF4ALPHA**, CEBPA:CEBPGAMMA**, AP1:STAT**, ETS:RUSH1A*, TBP:YY1* | |
Tonsil | 158 | 10 | CEBP:CEBPGAMMA**, NF1:P300, CACD:TAL1BETAE47*, PPARA:SP1*, OSF2:CDXA | [41] |
Whole blood | 132 | 8 | CEBPGAMMA:CEBPGAMMA**, PPARA:SP3*, ETS:VMYB*, SP3:YY1*, NFAT:PLZF* | [41] |
Ovary | 127 | 9 | CEBPA:SREBP1, GATA_C:MAF, LRF:NKX25, NF1:ZIC3, CHOP:PAX4 | Â |
Testis | 149 | 9 | CEBPGAMMA:CEBPGAMMA**, DR4:SPZ1*, POU3F2:PAX4, MYOGNF1:ZIC3, MYOGNF1:SP1 | [41] |
Testis germ cell | 136 | 8 | HAND1E47:SPZ1*, SP3:WT1, DBP:TBP, TEL2:LRF, POU3F2:COUP_DR1 | Â |
Testis interstitial | 115 | 5 | CEBP:CEBPGAMMA**, MYOGNF1:SPZ1*, DR4:SPZ1*, CEBPGAMMA:HMGIY, EBOX:SREBP1 | [41] |
Testis leydig cell | 135 | 6 | MYOGNF1:SPZ1*, FAC1:FOXJ2, TTF1:PPARA, GATA4:RUSH1A, HOXA4:OCT | Â |
Testis seminiferous tubule | 157 | 9 | STAT:STAT**, DR4:SPZ1*, FAC1:FOXJ2, AHRHIF:AP2ALPHA, CMAF:PPARA | [56] |
Adrenal cortex | 147 | 17 | CEBP:NFAT**, PPARA:SP1, HMGIY:ZF5_B, AP2:TST1, AP2ALPHA:TST1 | [57] |
Adrenal gland | 157 | 8 | PAX3:WT1, PPARA:SP3, TAL1BETAE47:CRX, DR3:SP3, CETS1P54:OCT | Â |
Fetal thyroid | 127 | 9 | CEBPA:CEBPGAMMA**, TST1:PAX2, CART1:PPARA, DR3:SP3, AP2:PPARA | [41] |
Pituitary gland | 133 | 19 | EBOX:P300, OSF2:YY1, AP2:PPARA, SP3:WT1, EGR1:ZF5_B* | Â |
Prostate | 176 | 12 | CEBPA:ETS**, EBOX:ETS**, ETS:VDR**, AP1:DR3, KROX:NF1 | |
Salivary gland | 132 | 11 | CEBPGAMMA:CEBPGAMMA**, AP2:POU3F2, TTF1:TTF1, CEBPA:CEBPGAMMA, EGR1:P300 | [41] |
Thyroid | 122 | 11 | CEBPA:CEBPGAMMA**, PPARA:SREBP1, GRE_C:SREBP1, MINI19_B:DR3, CMAF:YY1 | [41] |
721 B lymphoblasts | 168 | 11 | CART1:YY1, CP2:ZIC3, HMGIY:PAX4, DBP:TTF1, TEL2:P300 | Â |
Colorectal adenocarcinoma | 143 | 11 | FOXJ2:EFC, CART1:HOXA4, MINI19_B:DR4, SP3:WT1, OCT4:PAX2 | Â |
Leukemia chronic myelegenous | 151 | 9 | TCF11:NFAT, NCX:PAX2, ETF:SRY, NF1:ZIC3, AP2ALPHA:AREB6 | Â |
Leukemia lymphoblastic | 156 | 17 | AP2ALPHA:PAX4, CEBPA:PLZF, AP2ALPHA:TST1, AP2:PPARA, HMGIY:ZF5_B | Â |
Leukemia promyelocytic | 154 | 6 | CEBPGAMMA:CEBPGAMMA**, DR4:SPZ1, CEBPA:FAC1, P300:ZIC3, CP2:ZIC3 | [41] |
Lymphoma burkitts daudi | 147 | 12 | ETS:MYB**, CETS1P54:WT1, CP2:P300, CP2:EBOX, MINI19_B:WT1 | [59] |
Lymphoma burkitts Raji | 131 | 5 | NFAT:OCT1**, PPARA:SP3, E2A:MYOGNF1, CETS1P54:MYB, AREB6:CDPCR3 | |
Adipocyte | 142 | 14 | PPARA:SP1, EGR1:ZF5_B, SP3:SP3, AP2:SRY, PPARA:WT1 | Â |
Appendix | 136 | 8 | CEBP:NFAT**, ETS:VDR**, TAL1BETAE47:TEL2, SP3:WT1, DR4:SP3 | [57] |
Atrioventricular node | 140 | 13 | ETS:GRE_C, AREB6:PPARA, ETF:HOXA4, GEN_INI3_B:GEN_INI3_B, AP2:OCT4 | Â |
Bronchial epithelial cells | 152 | 14 | TTF1:SP1, POU3F2:GATA4, AP2ALPHA:TTF1, CACD:MAZ, CEBPA:GATA4 | Â |
Placenta | 132 | 5 | CEBPA:CEBPGAMMA**, SP3:WT1*, DEC:PAX5, NKX25:STAT1, PPARA:SP1 | [41] |
Skin | 156 | 20 | CEBPA:CEBPGAMMA**, HNF4ALPHA:PPARA, HMGIY:OCT4, CEBPGAMMA:PLZF, AP2ALPHA:CP2 | [41] |
Trachea | 146 | 12 | CEBPA:CEBPGAMMA**, CEBP:PAX4, CETS1P54:PPARA, AP2:XVENT1, AP2ALPHA:TST1 | [41] |