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Table 2 B. azoricus genes putatively involved in immune response and inflammatory reactions.

From: High-throughput sequencing and analysis of the gill tissue transcriptome from the deep-sea hydrothermal vent mussel Bathymodiolus azoricus

Function Gene Ontology n° Gene Ontology description
Peptidoglycan Recognition protein (PGRP) GO: 0008745 N-acetylmuramoyl-L-alanine amidase activity
Chitin binding protein GO:0008061; GO:0006030 Chitin binding; chitin metabolic process
Galectin 4-like protein GO:0005529 Sugar binding
Rhamnose-binding lectin GO:0005529 Sugar binding
Thrombospondin-like glycoprotein GO:0007155; GO:0033627 Cell adhesion; cell adhesion mediated by integrin
Glycoside hydrolase, Chitinase-like GO:0005975 Carbohydrate metabolic process
Mannose-6-phosphate receptor GO:0005537 Mannose binding
Contactin associated protein 2 GO:0007155; GO:0005515 Cell adhesion; protein binding
Tissue inhibitor of metalloproteinase GO:0008191; GO:0005578 Metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix
Serpin (serine protease inhibitor) GO:0004867 Serine-type endopeptidase inhibitor activity
α2-Macroblobulin (thioester-containing protein) GO:0004866 Endopeptidase inhibitor activity
Syndecan binding protein GO:0007265; GO:0005137 Ras protein signal transduction; interleukin-5 receptor binding
Fibrinogen (pattern recognition receptor) GO:0007165; GO:0005102 signal transduction; receptor binding
Ficolin (opsonin, contain fibrinogen and collagen-like domains) GO:0007165;GO:0005102 GO:0008228 signal transduction; receptor binding; opsonization
Scavenger receptor cysteine-rich protein (SRCR) GO:0005044 Scavenger receptor activity
LBP/BPI (LPS binding, Crassostrea homologue) GO:0008289 Lipid binding
Toll-interleukin receptor GO:0045087; GO:0007165 Innate immune response; signal transduction
Myd88 GO:0004888 Transmembrane receptor activity
TRAF (TNF receptor-associated factor) GO:0007165; GO:0042981 Signal transduction; regulation of apoptosis
IRAK GO:0019221; GO:0051092 Cytokine-mediated signaling pathway; regulation of NF-κB
MAPK GO:0004672; GO:0006468 Protein kinase activity; protein amino acid phosphorylation
p38 GO:0004672; GO:0051403 Protein kinase activity; stress-activated MAPK cascade
Notch homologue GO:0007411; GO: 0007219 Axon guidance; Notch signaling pathway
EGF receptor GO:0007173; GO:0007165 Epidermal growth factor receptor signaling Pathway; signal transduction
TNF receptor GO:0007165; GO:0042981 Signal transduction; regulation of apoptosis
Fibropellin homologue GO:0005509; GO:0005515 Calcium ion binding; protein binding
Laminin_EGF GO:0005539 Glycosaminoglycan binding
Cadherin (EGF domain containing) GO:0016020; GO:0007156 Membrane;homophilic cell adhesion
Integrin (fibronectin receptor) GO:0007155; GO:0007229 Cell adhesion; integrin mediated signaling pathway
Nuclear Factor κB inhibitor IPR015681 (InterPro) Regulation of NF-κB activity
STAT GO:0004871; GO:0045449 Signal transducer activity; regulation of transcription
SH2 motif(Src homology 2 GO:0007165; GO:0018108 Signal transduction; peptidyl-tyrosine phosphorylation
P53 GO:0006915; GO:0034984 Apoptosis; cellular response to DNA damage stimulus
AP-1 (Proto-oncogene c-jun) GO:0003700; GO:0045449 Transcription factor activity; regulation of transcription
Tal (Crassostrea homologue) GO:0045449; GO:0030528 Regulation of transcription; transcription regulator activity
Effector and modulator molecules   
Defensin (big defensin) GO:0006952 Defense response
Cytolysin GO:0009404 Toxin metabolic process
Apolipoprotein (plasminogen) GO:0007596; GO:0004252 Blood coagulation; serine-type endopeptidase activity
TNF (LPS-induced, α factor) GO:0006955; GO:0006952 Immune response; defense response
Interferon GO:0042742 Defense response to bacterium; regulation of innate immune response
TGF GO:0006954; GO:0006917 Inflammatory response; induction of apoptosis
Glutatione peroxidase GO:0004602; GO:0006979 Glutathione peroxidase activity; response to oxidative stress
Prostaglandin synthase/cyclooxygenase GO:0006979; GO:0004601 Response to oxidative stress; peroxidase activity
Fibronectin GO:0001968 Fibronectin binding
Metalloproteinase GO:0004222; GO:0005578 Metalloendopeptidase activity; proteinaceous extracellular matrix
Metallothionein GO:0046872 Metal ion binding
Ferritin GO:0006879 Cellular iron ion homeostasis
Tenascin GO:0009611; GO:0007155 Cell adhesion; response to wounding
Glucose-regulated protein 94 GO:0006950 Response to stress